Racial Differences in Urinary F2‐Isoprostane Levels and the Cross‐Sectional Association With bmi

Racial Differences in Urinary F2‐Isoprostane Levels and the Cross‐Sectional Association With bmi

Levels of four urinary F2‐isoprostanes (F2‐IsoPs) were examined in a large sample of the Insulin Resistance Atherosclerosis Study (IRAS) multiethnic cohort: 237 African Americans (AAs), 342 non‐Hispanic whites (NHWs), and 275 Hispanic whites (HWs). F2‐IsoP isomers — iPF2a‐III, 2,3‐dinor‐iPF2a‐III, i...

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Veröffentlicht in:Obesity (Silver Spring, Md.) Md.), 2012-10, Vol.20 (10), p.2147-2150
Hauptverfasser: Il'yasova, Dora, Wang, Frances, Spasojevic, Ivan, Base, Karel, D'Agostino, Ralph B., Wagenknecht, Lynne E.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
African Americans - statistics & numerical data
Aged
Atherosclerosis - ethnology
Atherosclerosis - urine
Biomarkers
Biomarkers - urine
Body Mass Index
Cohort Studies
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - urine
Epidemiology
European Continental Ancestry Group - statistics & numerical data
F2-Isoprostanes - urine
Female
Hispanic Americans - statistics & numerical data
Humans
Insulin Resistance
Male
Middle Aged
Obesity
Obesity - ethnology
Obesity - urine
Oxidative Stress
Prospective Studies
Race
Risk factors
Tandem Mass Spectrometry
United States - epidemiology
Weight Gain
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Zusammenfassung:Levels of four urinary F2‐isoprostanes (F2‐IsoPs) were examined in a large sample of the Insulin Resistance Atherosclerosis Study (IRAS) multiethnic cohort: 237 African Americans (AAs), 342 non‐Hispanic whites (NHWs), and 275 Hispanic whites (HWs). F2‐IsoP isomers — iPF2a‐III, 2,3‐dinor‐iPF2a‐III, iPF2a‐VI, and 8,12‐iso‐iPF2a‐VI — were measured in 854 urine samples using liquid chromatography with tandem mass spectrometry detection. In AAs, levels of all four F2‐IsoPs were lower compared with NHWs and HWs (P values 0.2), and positive associations among whites (P values
ISSN:1930-7381
1930-739X
DOI:10.1038/oby.2012.170