Implementing Personalized Medicine: Development of a Cost-Effective Customized Pharmacogenetics Genotyping Array

Although there is increasing evidence to support the implementation of pharmacogenetics in certain clinical scenarios, the adoption of this approach has been limited. The advent of preemptive and inexpensive testing of critical pharmacogenetic variants may overcome barriers to adoption. We describe...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2012-10, Vol.92 (4), p.437-439
Hauptverfasser:	Johnson, J A, Burkley, B M, Langaee, T Y, Clare-Salzler, M J, Klein, T E, Altman, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	Cost-Benefit Analysis - economics Cost-Benefit Analysis - methods Cost-Benefit Analysis - trends Genotype Humans Oligonucleotide Array Sequence Analysis - economics Oligonucleotide Array Sequence Analysis - methods Oligonucleotide Array Sequence Analysis - trends Pharmacogenetics - economics Pharmacogenetics - methods Pharmacogenetics - trends Polymorphism, Single Nucleotide - genetics Precision Medicine - economics Precision Medicine - methods Precision Medicine - trends
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Zusammenfassung:	Although there is increasing evidence to support the implementation of pharmacogenetics in certain clinical scenarios, the adoption of this approach has been limited. The advent of preemptive and inexpensive testing of critical pharmacogenetic variants may overcome barriers to adoption. We describe the design of a customized array built for the personalized‐medicine programs of the University of Florida and Stanford University. We selected key variants for the array using the clinical annotations of the Pharmacogenomics Knowledgebase (PharmGKB), and we included variants in drug metabolism and transporter genes along with other pharmacogenetically important variants. Clinical Pharmacology & Therapeutics (2012); 92 4, 437–439. doi:10.1038/clpt.2012.125
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2012.125