Association between migraine and HLA-DRB1 gene polymorphisms

Association between migraine and HLA-DRB1 gene polymorphisms

We examined the distribution of HLA-DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased...

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Veröffentlicht in:Journal of headache and pain 2005-09, Vol.6 (4), p.185-187
Hauptverfasser: Rainero, Innocenzo, Fasano, Edvige, Rubino, Elisa, Rivoiro, Chiara, Valfrè, Walter, Gallone, Salvatore, Savi, Lidia, Gentile, Salvatore, Lo Giudice, Rossana, De Martino, Paola, Dall'Omo, Anna Maria, Pinessi, Lorenzo
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Female
Gene loci
Genetic Predisposition to Disease
Genetics
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Italy
Male
Middle Aged
Migraine
Migraine with Aura - genetics
Migraine without Aura - genetics
Polymorphism
Polymorphism, Genetic
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Zusammenfassung:We examined the distribution of HLA-DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA-DRB1**16 allele was significantly increased (p
ISSN:1129-2369
1129-2377
DOI:10.1007/s10194-005-0180-3