Osteocyte RANKL: New insights into the control of bone remodeling

The idea that osteoblasts, or their progenitors, support osteoclast formation by expressing the cytokine receptor activator of NFkB ligand (RANKL) is a widely held tenet of skeletal biology. Two recent studies provide evidence that osteocytes, and not osteoblasts or their progenitors, are the major...

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Veröffentlicht in:	Journal of bone and mineral research 2012-03, Vol.27 (3), p.499-505
Hauptverfasser:	Xiong, Jinhu, O'Brien, Charles A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomechanical Phenomena BONE REMODELING Bone Remodeling - physiology Fundamental and applied biological sciences. Psychology Hormones - physiology Humans OSTEOBLAST OSTEOCLAST OSTEOCYTE Osteocytes - metabolism RANK Ligand - physiology RANKL Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
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Beschreibung
Zusammenfassung:	The idea that osteoblasts, or their progenitors, support osteoclast formation by expressing the cytokine receptor activator of NFkB ligand (RANKL) is a widely held tenet of skeletal biology. Two recent studies provide evidence that osteocytes, and not osteoblasts or their progenitors, are the major source of RANKL driving osteoclast formation in cancellous bone. The goal of this review is to highlight the results of these new studies and discuss their implications for our understanding of bone remodeling. © 2012 American Society for Bone and Mineral Research
ISSN:	0884-0431 1523-4681
DOI:	10.1002/jbmr.1547