Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells

Protein acetylation has been implicated in playing an important role during mitotic progression. Aurora B kinase is known to play a critical role in mitosis. However, whether Aurora B is regulated by acetylation is not known. Using IP with an anti‐acetyl lysine antibody, we identified Aurora B as an...

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Veröffentlicht in:	The FASEB journal 2012-10, Vol.26 (10), p.4057-4067
Hauptverfasser:	Fadri‐Moskwik, Maria, Weiderhold, Kimberly N., Deeraksa, Arpaporn, Chuang, Carol, Pan, Jing, Lin, Sue‐Hwa, Yu‐Lee, Li‐Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Aurora Kinase B Aurora Kinases Cell Line, Tumor HDAC3 Histone Deacetylases - metabolism Humans Immunoblotting Kinetochores - metabolism kinetochore‐microtubule attachment Male Microscopy, Fluorescence Microtubules - metabolism Mitosis - genetics Mitosis - physiology mitotic spindle post‐translational modification Prostatic Neoplasms - enzymology Prostatic Neoplasms - metabolism Protein Processing, Post-Translational Protein Serine-Threonine Kinases - metabolism Research Communications
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Zusammenfassung:	Protein acetylation has been implicated in playing an important role during mitotic progression. Aurora B kinase is known to play a critical role in mitosis. However, whether Aurora B is regulated by acetylation is not known. Using IP with an anti‐acetyl lysine antibody, we identified Aurora B as an acetylated protein in PC3 prostate cancer cells. Knockdown of HDAC3 or inhibiting HDAC3 deacetylase activity led to a significant increase (P
ISSN:	0892-6638 1530-6860
DOI:	10.1096/fj.12-206656