Phencyclidine/schizophrenia: one view toward the past, the other to the future

The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ke...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Schizophrenia bulletin 2012-09, Vol.38 (5), p.914-919
Hauptverfasser:	Domino, Edward F, Luby, Elliot D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics - history Animals Disease Models, Animal History, 20th Century History, 21st Century Humans Invited Themed Neuropharmacology - history Phencyclidine - history Psychoses, Substance-Induced - history Schizophrenia - history Street Drugs - history
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.
ISSN:	0586-7614 1745-1701
DOI:	10.1093/schbul/sbs011