Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents

Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 and 5, and the tripodal donor 1. The cytotoxicity of 8 was found to be considerably stronger than that of cisplatin. The complex 8 inhibited tumor cell proliferation by interfering into regulatory pat...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (18), p.5184-5186
Hauptverfasser:	Vajpayee, Vaishali, Yang, Yoon Jung, Kang, Se Chan, Kim, Hyunuk, Kim, In Su, Wang, Ming, Stang, Peter J, Chi, Ki-Whan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology apoptosis cell cycle Cell Line, Tumor cell proliferation Cell Proliferation - drug effects chemical reactions cisplatin Cisplatin - chemistry Crystallography, X-Ray cytotoxicity Drug Screening Assays, Antitumor Humans Ligands Molecular Structure neoplasm cells Organometallic Compounds - chemistry Organometallic Compounds - pharmacology ruthenium Ruthenium - chemistry Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 and 5, and the tripodal donor 1. The cytotoxicity of 8 was found to be considerably stronger than that of cisplatin. The complex 8 inhibited tumor cell proliferation by interfering into regulatory pathways of the cell cycle via apoptosis.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c1cc10167f