Association of a functional polymorphism (Gln261Arg) in 12-lipoxygenase with breast cancer

Association of a functional polymorphism (Gln261Arg) in 12-lipoxygenase with breast cancer

The overexpression of arachidonyl lipoxygenase-12 (ALOX12) in breast cancer has been reported. Hence, we examined whether a non-synonymous polymorphism of ALOX12 (mRNA, A835G; Gln261Arg) is associated with breast cancer in females. The polymorphism was detected in genomic DNA by PCR-RFLP. The associ...

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Veröffentlicht in:Experimental and therapeutic medicine 2011-03, Vol.2 (2), p.317-323
Hauptverfasser: PRASAD, VIDUDALA V.T.S, KOLLI, PADMA, MOGANTI, DIVYA
Format: Artikel
Sprache:eng
Schlagworte:
12-lipoxygenase
2-hydroxyeicosatetraenoic acid
arachidonyl lipoxygenase-12
breast cancer
lipoxygenase
polymorphism and gene variants
single-nucleotide polymorphism
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Zusammenfassung:The overexpression of arachidonyl lipoxygenase-12 (ALOX12) in breast cancer has been reported. Hence, we examined whether a non-synonymous polymorphism of ALOX12 (mRNA, A835G; Gln261Arg) is associated with breast cancer in females. The polymorphism was detected in genomic DNA by PCR-RFLP. The association between the A835G polymorphism and breast cancer risk was measured by odds ratio (OR) with 95% confidence intervals (CIs) using Fisher's exact test, and differences were considered significant at p
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2011.209