Deterministic or Stochastic Choices in Retinal Neuron Specification

Deterministic or Stochastic Choices in Retinal Neuron Specification

There are two views on vertebrate retinogenesis: a deterministic model dependent on fixed lineages and a stochastic model in which choices of division modes and cell fates cannot be predicted. In this issue of Neuron, He et al. (2012) address this question in zebrafish using live imaging and mathema...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2012-09, Vol.75 (5), p.739-742
Hauptverfasser: Chen, Zhenqing, Li, Xin, Desplan, Claude
Format: Artikel
Sprache:eng
Schlagworte:
Cell division
Cloning
Danio rerio
Freshwater
Genes
Insects
Nervous system
Neurons
Photoreceptors
Retina
Stochastic models
Transcription factors
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Zusammenfassung:There are two views on vertebrate retinogenesis: a deterministic model dependent on fixed lineages and a stochastic model in which choices of division modes and cell fates cannot be predicted. In this issue of Neuron, He et al. (2012) address this question in zebrafish using live imaging and mathematical modeling.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2012.08.008