Elevated rheumatoid factor and long term risk of rheumatoid arthritis: a prospective cohort study

Objective To test whether elevated concentration of rheumatoid factor is associated with long term development of rheumatoid arthritis.Design A prospective cohort study, the Copenhagen City Heart Study. Blood was drawn in 1981-83, and participants were followed until 10 August 2010.Setting Copenhage...

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Veröffentlicht in:	BMJ (Online) 2012-09, Vol.345 (7878), p.15-15
Hauptverfasser:	Nielsen, Sune F, Bojesen, Stig E, Schnohr, Peter, Nordestgaard, Børge G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Alcohol Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - etiology Blood & organ donations Blood plasma Cigarettes Classification Cohort analysis Cohort studies Connective Tissue Disease Degenerative Joint Disease Epidemiologic Studies Female Health risk assessment Hospitalization Humans Hypotheses Immunoglobulin M Immunoglobulins Immunology (Including Allergy) Kaplan-Meier Estimate Male Middle Aged Musculoskeletal Syndromes Patients Peptides Population Proportional Hazards Models Prospective Studies Proteins Registration Rheumatic diseases Rheumatoid Arthritis Rheumatoid factor Rheumatoid Factor - blood Rheumatology Risk Factors ROC Curve Sex Factors Smoking Smoking - adverse effects Tobacco Young Adult
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Beschreibung
Zusammenfassung:	Objective To test whether elevated concentration of rheumatoid factor is associated with long term development of rheumatoid arthritis.Design A prospective cohort study, the Copenhagen City Heart Study. Blood was drawn in 1981-83, and participants were followed until 10 August 2010.Setting Copenhagen general population.Participants 9712 white Danish individuals from the general population aged 20-100 years without rheumatoid arthritis at study entry.Main outcome measures Rheumatoid arthritis according to baseline plasma IgM rheumatoid factor level categories of 25-50, 50.1-100, and >100, versus
ISSN:	0959-8138 1756-1833 1756-1833
DOI:	10.1136/bmj.e5244