Identification of new SLE-associated genes with a two-step Bayesian study design

In our earlier study, we utilized a Bayesian design to probe the association of ∼1000 genes (∼10 000 single-nucleotide polymorphisms (SNPs)) with systemic lupus erythematosus (SLE) on a moderate number of trios of parents and children with SLE. Two genes associated with SLE, with a multitest-correct...

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Veröffentlicht in:	Genes and immunity 2009-07, Vol.10 (5), p.446-456
Hauptverfasser:	Armstrong, D L, Reiff, A, Myones, B L, Quismorio, F P, Klein-Gitelman, M, McCurdy, D, Wagner-Weiner, L, Silverman, E, Ojwang, J O, Kaufman, K M, Kelly, J A, Merrill, J T, Harley, J B, Bae, S-C, Vyse, T J, Gilkeson, G S, Gaffney, P M, Moser, K L, Putterman, C, Edberg, J C, Brown, E E, Ziegler, J, Langefeld, C D, Zidovetzki, R, Jacob, C O
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Bayes Theorem Bayesian analysis Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Children Diagnosis Disease Gene Expression Genes Genetic aspects Genetic Predisposition to Disease Genetic screening Genome-Wide Association Study Genomes Hospitals Human Genetics Humans Hypotheses Immunity Immunology Interleukin 16 KLRG1 protein Lupus Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - genetics Medicine Neurosciences original-article Polymorphism, Single Nucleotide Probes Protein-tyrosine-phosphatase Rheumatology Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Systemic lupus erythematosus Toll-like receptors
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Beschreibung
Zusammenfassung:	In our earlier study, we utilized a Bayesian design to probe the association of ∼1000 genes (∼10 000 single-nucleotide polymorphisms (SNPs)) with systemic lupus erythematosus (SLE) on a moderate number of trios of parents and children with SLE. Two genes associated with SLE, with a multitest-corrected false discovery rate (FDR) of
ISSN:	1466-4879 1476-5470
DOI:	10.1038/gene.2009.38