Found in translation of mTOR signaling

The mammalian target of rapamycin （mTOR） protein kinase regulates a wide variety of cellular processes, including protein synthesis, yet the downstream translational program under the control of mTOR is poorly understood. Two recent studies by Hsieh et aL and Thoreen et aL now start to address this issue, and uncover a subset of genes translationally regulated by oncogenic roTOR signaling that may contribute to tumorigenesis.