Sleep disturbance, cytokines, and fatigue in women with ovarian cancer

Highlight ► We examined relationships at two time points between sleep, fatigue, and interleukin-6 (IL-6) in ovarian cancer patients. ► Higher levels of IL-6 were associated with greater sleep disturbance at pre-surgery and one year post diagnosis. ► The association between IL-6 and fatigue at pre-s...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2012-10, Vol.26 (7), p.1037-1044
Hauptverfasser:	Clevenger, Lauren, Schrepf, Andrew, Christensen, Desire, DeGeest, Koen, Bender, David, Ahmed, Amina, Goodheart, Michael J, Penedo, Frank, Lubaroff, David M, Sood, Anil K, Lutgendorf, Susan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Affect - physiology Aged Allergy and Immunology Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Anxiety - psychology Body Mass Index Cancer Circadian rhythm Cytokines - blood Demography Fatigue Fatigue - etiology Female Health Behavior Humans Interleukin-6 Interleukin-6 - blood Middle Aged Ovarian cancer Ovarian Neoplasms - complications Ovarian Neoplasms - drug therapy Ovarian Neoplasms - surgery Psychiatry Sickness behaviors Sleep Sleep Wake Disorders - etiology Treatment Outcome
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Zusammenfassung:	Highlight ► We examined relationships at two time points between sleep, fatigue, and interleukin-6 (IL-6) in ovarian cancer patients. ► Higher levels of IL-6 were associated with greater sleep disturbance at pre-surgery and one year post diagnosis. ► The association between IL-6 and fatigue at pre-surgery was no longer significant when controlling for sleep. ► Changes in sleep over time were associated with percent change in IL-6 from pre-surgery to one year.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2012.04.003