Progress towards the synthesis of Urukthapelstatin A and two analogues

Progress towards the synthesis of Urukthapelstatin A and two analogues

We report our progress towards the synthesis of Urukthapelstatin A (Ustat A) and two analogues. Our retrosynthetic strategy involved the synthesis of three fragments: a tri-heteroaromatic moiety, a phenyl oxazole fragment, and a dipeptide. Described are the syntheses of three unique tri-heteroaromat...

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Veröffentlicht in:Tetrahedron letters 2012-08, Vol.53 (32), p.4065-4069
Hauptverfasser: Pan, Chung-Mao, Lin, Chun-Chieh, Kim, Seong Jong, Sellers, Robert P, McAlpine, Shelli R
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Sprache:eng
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Zusammenfassung:We report our progress towards the synthesis of Urukthapelstatin A (Ustat A) and two analogues. Our retrosynthetic strategy involved the synthesis of three fragments: a tri-heteroaromatic moiety, a phenyl oxazole fragment, and a dipeptide. Described are the syntheses of three unique tri-heteroaromatic moieties. In addition, the corresponding linear precursors of Ustat A and two analogues are presented.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2012.05.105