mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase
Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cl...
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| Veröffentlicht in: | Nucleic acids research 1976-05, Vol.3 (5), p.1139-1149 |
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| container_title | Nucleic acids research |
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| creator | Morgan, R.A Cone, R.L Elgert, T.M |
| description | Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself. |
| doi_str_mv | 10.1093/nar/3.5.1139 |
| format | Article |
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Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. 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Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself.</description><subject>Ascorbic Acid</subject><subject>Benzoates - pharmacology</subject><subject>Binding Sites</subject><subject>Catalase - metabolism</subject><subject>Dimethyl Sulfoxide - pharmacology</subject><subject>DNA</subject><subject>Ethanol - pharmacology</subject><subject>Formates - pharmacology</subject><subject>Free Radicals</subject><subject>human nutrition</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Iodides - pharmacology</subject><subject>Kinetics</subject><subject>Mannitol - pharmacology</subject><subject>nutrition education</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Superoxides</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUlvFDEUhFuIbQjcOCLhE6f05Hnp7ZBDNIEEFIEQRERcrNfu1zMmvQy2e5Tk1-PJRGG5cLKsr6rsUiXJSw5zDpU8GNAdyHk251xWD5IZl7lIVZWLh8kMJGQpB1U-TZ55_wOAK56pJ8ljXvJCwiy56cmscLC-Z2PLjj8eMR8cDg2rHeElLonV12xjA_Z2YAu2JX5akxuvbEO317AitnZjIBPshpgbO_LbLIMBO_T0r6eJb00hgufJoxY7Ty_uzr3k_N3br4vT9OzTyfvF0VlqVAEhRcgaI7gppSjRcBnbNChkUxsOGZS5ACVr0wgFeYt5JXie87ICwYkKIbGWe8nhLnc91T01hobYsNNrZ3t013pEq_8mg13p5bjRUomqyKP_zZ3fjT8n8kH31hvqOhxonLwupSqLIiv-K-SVzKCCbeL-Tmjc6L2j9v4zHPR2Uh0n1VJnejtplL_6s8Bv8e2GEac7bH2gq3uK7lLnhSwyfXrxXX-Di88fTopSH0f9652-xVHj0lmvz78I4DEKlOJVJX8BJFO2uw</recordid><startdate>19760501</startdate><enddate>19760501</enddate><creator>Morgan, R.A</creator><creator>Cone, R.L</creator><creator>Elgert, T.M</creator><general>Oxford University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19760501</creationdate><title>mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase</title><author>Morgan, R.A ; Cone, R.L ; Elgert, T.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-a05dc21c8328ac13104da23dbc1050862043bcd2406fa692166189021ee723ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Ascorbic Acid</topic><topic>Benzoates - pharmacology</topic><topic>Binding Sites</topic><topic>Catalase - metabolism</topic><topic>Dimethyl Sulfoxide - pharmacology</topic><topic>DNA</topic><topic>Ethanol - pharmacology</topic><topic>Formates - pharmacology</topic><topic>Free Radicals</topic><topic>human nutrition</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>Iodides - pharmacology</topic><topic>Kinetics</topic><topic>Mannitol - pharmacology</topic><topic>nutrition education</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Superoxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morgan, R.A</creatorcontrib><creatorcontrib>Cone, R.L</creatorcontrib><creatorcontrib>Elgert, T.M</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morgan, R.A</au><au>Cone, R.L</au><au>Elgert, T.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>1976-05-01</date><risdate>1976</risdate><volume>3</volume><issue>5</issue><spage>1139</spage><epage>1149</epage><pages>1139-1149</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><abstract>Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>181730</pmid><doi>10.1093/nar/3.5.1139</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-1048 |
| ispartof | Nucleic acids research, 1976-05, Vol.3 (5), p.1139-1149 |
| issn | 0305-1048 1362-4962 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_342976 |
| source | Oxford University Press Journals Digital Archive legacy; MEDLINE; PubMed Central |
| subjects | Ascorbic Acid Benzoates - pharmacology Binding Sites Catalase - metabolism Dimethyl Sulfoxide - pharmacology DNA Ethanol - pharmacology Formates - pharmacology Free Radicals human nutrition Hydrogen Peroxide - pharmacology Iodides - pharmacology Kinetics Mannitol - pharmacology nutrition education Superoxide Dismutase - metabolism Superoxides |
| title | mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase |
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