mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase

Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cl...

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Veröffentlicht in:	Nucleic acids research 1976-05, Vol.3 (5), p.1139-1149
Hauptverfasser:	Morgan, R.A, Cone, R.L, Elgert, T.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic Acid Benzoates - pharmacology Binding Sites Catalase - metabolism Dimethyl Sulfoxide - pharmacology DNA Ethanol - pharmacology Formates - pharmacology Free Radicals human nutrition Hydrogen Peroxide - pharmacology Iodides - pharmacology Kinetics Mannitol - pharmacology nutrition education Superoxide Dismutase - metabolism Superoxides
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Zusammenfassung:	Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself.
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/3.5.1139