Key role of the positive feedback between PGE2 and COX2 in the biology of myeloid-derived suppressor cells

PGE 2 is the key factor needed for MDSCs development, accumulation and functional stability. PGE 2 initiates an EP2/EP4-mediated positive feedback between COX2 and PGE 2 in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions...

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Veröffentlicht in:	Oncoimmunology 2012-08, Vol.1 (5), p.762-764
Hauptverfasser:	Obermajer, Nataša, Kalinski, Pawel
Format:	Artikel
Sprache:	eng
Schlagworte:	Author's View Binding Biology Bioscience Calcium Cancer Cell COX2 Cycle human immune dysfunction immunotherapy Landes myeloid-derived suppressor cells Organogenesis PGE Proteins transplantation
Online-Zugang:	Volltext
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