Key role of the positive feedback between PGE2 and COX2 in the biology of myeloid-derived suppressor cells

Key role of the positive feedback between PGE2 and COX2 in the biology of myeloid-derived suppressor cells

PGE 2 is the key factor needed for MDSCs development, accumulation and functional stability. PGE 2 initiates an EP2/EP4-mediated positive feedback between COX2 and PGE 2 in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology 2012-08, Vol.1 (5), p.762-764
Hauptverfasser: Obermajer, Nataša, Kalinski, Pawel
Format: Artikel
Sprache:eng
Schlagworte:
Author's View
Binding
Biology
Bioscience
Calcium
Cancer
Cell
COX2
Cycle
human
immune dysfunction
immunotherapy
Landes
myeloid-derived suppressor cells
Organogenesis
PGE
Proteins
transplantation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:PGE 2 is the key factor needed for MDSCs development, accumulation and functional stability. PGE 2 initiates an EP2/EP4-mediated positive feedback between COX2 and PGE 2 in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated attraction to cancer environment, providing convenient immunotherapeutic targets.
ISSN:2162-4011
2162-402X
DOI:10.4161/onci.19681