Gold(I)-Catalyzed Enantioselective Intramolecular Dehydrative Amination of Allylic Alcohols with Carbamates

Gold(I)-Catalyzed Enantioselective Intramolecular Dehydrative Amination of Allylic Alcohols with Carbamates

Aliphatic nitrogen heterocycles—either five‐ or six‐membered—are formed in high yield and with up to 94 % ee when a 1:2 mixture of [(S)‐2](AuCl)2 and AgClO4 is used as the catalyst for the title reaction.

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Veröffentlicht in:Angewandte Chemie International Edition 2012-02, Vol.51 (6), p.1405-1407
Hauptverfasser: Mukherjee, Paramita, Widenhoefer, Ross A.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Aliphatic compounds
Amination
Amines - chemical synthesis
Amines - chemistry
asymmetric synthesis
Carbamates - chemistry
Catalysis
Catalysts
Combinatorial Chemistry Techniques
Cyclization
Dehydration
gold
Gold - chemistry
nitrogen heterocycles
Propanols - chemistry
Stereoisomerism
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Beschreibung
Zusammenfassung:Aliphatic nitrogen heterocycles—either five‐ or six‐membered—are formed in high yield and with up to 94 % ee when a 1:2 mixture of [(S)‐2](AuCl)2 and AgClO4 is used as the catalyst for the title reaction.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201107877