Nuclear magnetic resonance of nucleotide-amidates. Investigation of the secondary structure of methylester of deoxyadenylyl - (5′ - 3′) - deoxyadenylyl - (5′→N) - L - phenylalanine

The secondary structure of methyl ester of deoxyadenylyl - (5′ – 3′) - deoxyadenylyl - (5′→ N) - L-phenylalanine / L- PheOMe - d(pApA)/ was investigated using proton magnetic resonance. The folded conformation stabilized by hydrophobic interactions in aqueous solution was shown for this compound. The investigation of the chemical shifts of aromatic protons of L- PheOMe - d(pApA) permitted us to construct the conformational model of this compound.