No Effect of Raltegravir Intensification on Viral Replication Markers in the Blood of HIV-1-Infected Patients Receiving Antiretroviral Therapy

Controversy continues regarding the extent of ongoing viral replication in HIV-1-infected patients on effective antiretroviral therapy (ART). Adding an additional potent agent, such as raltegravir, to effective ART in patients with low-level residual viremia may reveal whether there is ongoing HIV-1...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2012-03, Vol.59 (3), p.229-235
Hauptverfasser:	GANDHI, Rajesh T, COOMBS, Robert W, WIEGAND, Ann, KEARNEY, Mary, JACOBSON, Jeffrey M, D'AQUILA, Richard, LEDERMAN, Michael M, MELLORS, John W, ERON, Joseph J, CHAN, Ellen S, BOSCH, Ronald J, LU ZHENG, MARGOLIS, David M, READ, Sarah, KALLUNGAL, Beatrice, MING CHANG, GOECKER, Erin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - administration & dosage Antiretroviral drugs Biological and medical sciences CD4 Lymphocyte Count Deoxyribonucleic acid DNA DNA, Viral - blood DNA, Viral - chemistry DNA, Viral - genetics Drug therapy Fundamental and applied biological sciences. Psychology HIV HIV Infections - blood HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Long Terminal Repeat - drug effects HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Human viral diseases Humans Indexing in process Infectious diseases Lymphocyte Activation - drug effects Medical sciences Microbiology Miscellaneous Polymerase Chain Reaction Pyrrolidinones - administration & dosage Raltegravir Potassium RNA, Viral - blood RNA, Viral - genetics T cell receptors T-Lymphocytes - drug effects T-Lymphocytes - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viremia - blood Viremia - drug therapy Viremia - immunology Viremia - virology Virology Virus Replication - drug effects
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Zusammenfassung:	Controversy continues regarding the extent of ongoing viral replication in HIV-1-infected patients on effective antiretroviral therapy (ART). Adding an additional potent agent, such as raltegravir, to effective ART in patients with low-level residual viremia may reveal whether there is ongoing HIV-1 replication. We previously reported the outcome of a randomized placebo-controlled study of raltegravir intensification in patients on ART with HIV-1 RNA
ISSN:	1525-4135 1944-7884
DOI:	10.1097/QAI.0b013e31823fd1f2