Methods of dendritic spine detection: From Golgi to high-resolution optical imaging

Methods of dendritic spine detection: From Golgi to high-resolution optical imaging

Highlights ► Golgi staining and manual spine identification have provided insight into neurodegeneration. ► Advances in microscopy and tissue labeling have allowed in vivo studies in animals. ► Automated spine algorithms are necessary tools for a system-level scale study.

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Veröffentlicht in:Neuroscience 2013-10, Vol.251, p.129-140
Hauptverfasser: Mancuso, J.J, Chen, Y, Li, X, Xue, Z, Wong, S.T.C
Format: Artikel
Sprache:eng
Schlagworte:
dendritic spines
Dendritic Spines - ultrastructure
image analysis
informatics
microscopy
Microscopy - methods
Neurology
Optical Imaging - methods
Silver Staining - methods
transgenic mice
two-photon
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Zusammenfassung:Highlights ► Golgi staining and manual spine identification have provided insight into neurodegeneration. ► Advances in microscopy and tissue labeling have allowed in vivo studies in animals. ► Automated spine algorithms are necessary tools for a system-level scale study.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.04.010