Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses

We evaluated the left ventricle (LV) response to hypoxia by comparing male Sprague Dawley rats exposed for 7 days to normoxia (control; n=18), chronic sustained hypoxia (CSH; n=12) and chronic intermittent hypoxia (CIH; n=12). Out of the 168 inflammatory, extracellular matrix and adhesion molecule g...

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Veröffentlicht in:	Hypertension research 2012-08, Vol.35 (8), p.811-818
Hauptverfasser:	Ramirez, Trevi A, Jourdan-Le Saux, Claude, Joy, Anne, Zhang, Jianhua, Dai, Qiuxia, Mifflin, Steve, Lindsey, Merry L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Body Weight Cell Adhesion Molecules - metabolism Chronic Disease Extracellular Matrix - genetics Extracellular Matrix - pathology Gene Expression - genetics Hypoxia - physiopathology Inflammation - etiology Inflammation - genetics Inflammation - pathology Inflammation Mediators - metabolism Lung - pathology Male Myocardium - pathology Organ Size Original Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - genetics Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - pathology
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Zusammenfassung:	We evaluated the left ventricle (LV) response to hypoxia by comparing male Sprague Dawley rats exposed for 7 days to normoxia (control; n=18), chronic sustained hypoxia (CSH; n=12) and chronic intermittent hypoxia (CIH; n=12). Out of the 168 inflammatory, extracellular matrix and adhesion molecule genes evaluated, Ltb, Cdh4, Col5a1, Ecm1, MMP-11 and TIMP-2 increased in the LV (range: 87-138%), whereas Tnfrsf1a decreased 27%, indicating an increase in inflammatory status with CSH (all P
ISSN:	0916-9636 1348-4214
DOI:	10.1038/hr.2012.32