Low-density lipoprotein receptor gene transfer in hypercholesterolemic mice improves cardiac function after myocardial infarction

Left ventricular (LV) function post-myocardial infarction (MI) is adversely influenced by hypercholesterolemia independent of the severity of coronary atherosclerosis. The objective of this study was to evaluate whether lipid lowering by adenoviral low-density lipoprotein (LDL) receptor (AdLDLr) gen...

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Veröffentlicht in:	Gene therapy 2012-08, Vol.19 (8), p.860-871
Hauptverfasser:	Van Craeyveld, E, Jacobs, F, Gordts, S C, De Geest, B
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/75/2/1674 692/699/75/2099 692/700/565/201 Adenoviridae - genetics Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Arteriosclerosis Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology cardiomyocytes Care and treatment Cell Biology Cell receptors Cell structures and functions Cholesterol Cholesterol - blood Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Health aspects Health. Pharmaceutical industry Heart Heart attack Heart attacks Human Genetics Hypercholesterolemia Hypercholesterolemia - genetics Hypercholesterolemia - therapy Industrial applications and implications. Economical aspects LDLR gene Lipids lipoprotein receptors Lipoproteins Lipoproteins (low density) Low density lipoprotein receptors Medical sciences Mice Mice, Inbred C57BL Miscellaneous Molecular and cellular biology Mortality Muscle contraction Myocardial infarction Myocardial Infarction - complications Myocardial Infarction - mortality Myocardial Infarction - pathology Myocardial Infarction - physiopathology Nanotechnology Neovascularization, Physiologic Original original-article Receptor mechanisms Receptors, LDL - deficiency Receptors, LDL - genetics Rodents Stem cells Survival Transfusions. Complications. Transfusion reactions. Cell and gene therapy vascularization Ventricle Ventricular Function, Left - genetics Ventricular Remodeling - genetics
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Beschreibung
Zusammenfassung:	Left ventricular (LV) function post-myocardial infarction (MI) is adversely influenced by hypercholesterolemia independent of the severity of coronary atherosclerosis. The objective of this study was to evaluate whether lipid lowering by adenoviral low-density lipoprotein (LDL) receptor (AdLDLr) gene transfer in C57BL/6 LDL receptor (LDLr)-deficient mice beneficially affects ventricular remodeling and cardiac function post-MI independent of effects on the coronary circulation. AdLDLr transfer reduced plasma cholesterol by 77% ( P
ISSN:	0969-7128 1476-5462
DOI:	10.1038/gt.2011.147