Initial studies of the cytoplasmic FABP superfamily

Initial studies of the cytoplasmic FABP superfamily

Our colleagues and we have determined the complete primary structure of a low molecular weight cytoplasmic FABP (also known as z-protein) that binds to LCFAs with high affinities, obtained from rat liver.1) At the same time, we were the first to propose that rat FABP1, bovine FABP8 (MP-2), bovine CR...

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Veröffentlicht in:Proceedings of the Japan Academy, Series B Series B, 2010, Vol.86(3), pp.220-228
Hauptverfasser: ONO, Teruo, ODANI, Shoji
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Cattle
CRABP
CRBP
Cytoplasm - metabolism
FABP
Fatty Acid-Binding Proteins - chemistry
Fatty Acid-Binding Proteins - genetics
Fatty Acid-Binding Proteins - metabolism
FXR
Humans
Molecular Sequence Data
Multigene Family
Phylogeny
Rats
Review
RXR
α2U-globulin
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Zusammenfassung:Our colleagues and we have determined the complete primary structure of a low molecular weight cytoplasmic FABP (also known as z-protein) that binds to LCFAs with high affinities, obtained from rat liver.1) At the same time, we were the first to propose that rat FABP1, bovine FABP8 (MP-2), bovine CRBP and rat CRABP constituted a protein superfamily in 1982.2) Since then, extensive investigation of structures, functions and expressions has been carried out on a whole family of FABPs.3)–5) Analyses of rat heart FABP; FABP1, FABP3 and α2U-globulin expressed in rat kidney; discovery of ileal FABP6 (I-15P); and first application of FABP2 as a diagnostic marker also stand out in particular. (Communicated by Tamio YAMAKAWA, M.J.A.)
ISSN:0386-2208
1349-2896
DOI:10.2183/pjab.86.220