Biased excitable networks: how cells direct motion in response to gradients

Highlights ► The actin cytoskeleton in motile cells behaves as an excitable medium. ► This excitable behavior can account for the spontaneous migration of cells. ► Recent models show how chemoattractant signaling biases the site of excitability to direct cells. ► We demonstrate how persistence and p...

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Veröffentlicht in:	Current opinion in cell biology 2012-04, Vol.24 (2), p.245-253
Hauptverfasser:	Iglesias, Pablo A, Devreotes, Peter N
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Cell Movement Cell Polarity Chemotactic Factors - metabolism Chemotaxis Eukaryotic Cells - cytology Internal Medicine Signal Transduction
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights ► The actin cytoskeleton in motile cells behaves as an excitable medium. ► This excitable behavior can account for the spontaneous migration of cells. ► Recent models show how chemoattractant signaling biases the site of excitability to direct cells. ► We demonstrate how persistence and polarization can arise in biased, excitable networks. ► We discuss molecular mechanisms giving rise to excitability.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/j.ceb.2011.11.009