Gain and Loss of Function for Glutathione Synthesis: Impact on Advanced Atherosclerosis in Apo E Deficient Mice

Gain and Loss of Function for Glutathione Synthesis: Impact on Advanced Atherosclerosis in Apo E Deficient Mice

Glutamate-cysteine ligase (GCL) is the rate-limiting step in glutathione synthesis. The enzyme is a hetero-dimer composed of a catalytic subunit GCLC and a modifier subunit GCLM.

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Veröffentlicht in:Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-11, Vol.31 (11), p.2473-2482
Hauptverfasser: Callegari, Andrea, Liu, Yuhua, White, Collin C., Chait, Alan, Gough, Peter, Raines, Elaine W., Cox, David, Kavanagh, Terrance J., Rosenfeld, Michael E.
Format: Artikel
Sprache:eng
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Zusammenfassung:Glutamate-cysteine ligase (GCL) is the rate-limiting step in glutathione synthesis. The enzyme is a hetero-dimer composed of a catalytic subunit GCLC and a modifier subunit GCLM.
ISSN:1079-5642
1524-4636
DOI:10.1161/ATVBAHA.111.229765