Capsular switching in invasive Neisseria meningitidis, Brazil(1)

During the 1990s, an epidemic of B:4 Neisseria meningitidis infections affected Brazil. Subsequent increase in C:4 disease suggested B → C capsular switching. This study identified B → C switches within the sequence type 32 complex. Substantial disease related to capsular switching emphasizes the ne...

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Veröffentlicht in:	Emerging infectious diseases 2012-08, Vol.18 (8), p.1336-1338
Hauptverfasser:	Castiñeiras, Terezinha M P P, Barroso, David E, Marsh, Jane W, Tulenko, Mary M, Krauland, Mary G, Rebelo, Maria C, Harrison, Lee H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antigenic Variation - genetics bacteria Bacterial Capsules - genetics Brazil - epidemiology capsular switching Child Child, Preschool Dispatch Epidemics Female Genes Genotype Health aspects Humans Infant Male Meningitis Meningococcal infections Meningococcal Infections - epidemiology Middle Aged Multilocus Sequence Typing Neisseria meningitides Neisseria meningitidis, Serogroup B - classification Neisseria meningitidis, Serogroup B - genetics Neisseria meningitidis, Serogroup C - classification Neisseria meningitidis, Serogroup C - genetics Polysaccharides Sequence Analysis, DNA serogroup C Serotyping ST-32/ET-5 complex Vaccines Young Adult
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Zusammenfassung:	During the 1990s, an epidemic of B:4 Neisseria meningitidis infections affected Brazil. Subsequent increase in C:4 disease suggested B → C capsular switching. This study identified B → C switches within the sequence type 32 complex. Substantial disease related to capsular switching emphasizes the need for surveillance of circulating meningococcal strains to optimize disease control.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1808.111344