Superoxide‐lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

Summary To test the hypothesis that the antioxidant enzyme superoxide dismutase (SOD) mimetic TEMPOL improves arterial aging, young (Y, 4–6 months) and old (O, 26–28 months) male C57BL6 mice received regular or TEMPOL‐supplemented (1mM) drinking water for 3 weeks (n = 8 per group). Aortic superoxide...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Aging cell 2012-04, Vol.11 (2), p.269-276
Hauptverfasser:	Fleenor, Bradley S., Seals, Douglas R., Zigler, Melanie L., Sindler, Amy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Antioxidants - therapeutic use collagen Collagen - metabolism Cyclic N-Oxides - therapeutic use glycation endproducts inflammation Male Mice NADPH Oxidases - metabolism nitric oxide Oxidative Stress Rats Spin Labels superoxide dismutase Superoxides - metabolism Vascular Diseases - drug therapy
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!