Superoxide‐lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

Superoxide‐lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

Summary To test the hypothesis that the antioxidant enzyme superoxide dismutase (SOD) mimetic TEMPOL improves arterial aging, young (Y, 4–6 months) and old (O, 26–28 months) male C57BL6 mice received regular or TEMPOL‐supplemented (1mM) drinking water for 3 weeks (n = 8 per group). Aortic superoxide...

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Veröffentlicht in:Aging cell 2012-04, Vol.11 (2), p.269-276
Hauptverfasser: Fleenor, Bradley S., Seals, Douglas R., Zigler, Melanie L., Sindler, Amy L.
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Animals
Antioxidants - therapeutic use
collagen
Collagen - metabolism
Cyclic N-Oxides - therapeutic use
glycation endproducts
inflammation
Male
Mice
NADPH Oxidases - metabolism
nitric oxide
Oxidative Stress
Rats
Spin Labels
superoxide dismutase
Superoxides - metabolism
Vascular Diseases - drug therapy
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Zusammenfassung:Summary To test the hypothesis that the antioxidant enzyme superoxide dismutase (SOD) mimetic TEMPOL improves arterial aging, young (Y, 4–6 months) and old (O, 26–28 months) male C57BL6 mice received regular or TEMPOL‐supplemented (1mM) drinking water for 3 weeks (n = 8 per group). Aortic superoxide was 65% greater in O (P 
ISSN:1474-9718
1474-9726
DOI:10.1111/j.1474-9726.2011.00783.x