Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence

The present study searched for replicable risk genomic regions for alcohol and nicotine co‐dependence using a genome‐wide association strategy. The data contained a total of 3,143 subjects including 818 European‐American (EA) cases with alcohol and nicotine co‐dependence, 1,396 EA controls, 449 Afri...

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Veröffentlicht in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2012-06, Vol.159B (4), p.437-444
Hauptverfasser:	Zuo, Lingjun, Zhang, Fengyu, Zhang, Heping, Zhang, Xiang-Yang, Wang, Fei, Li, Chiang-Shan R., Lu, Lingeng, Hong, Jiang, Lu, Lin, Krystal, John, Deng, Hong-Wen, Luo, Xingguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictive behaviors Adult and adolescent clinical studies alcohol and nicotine co-dependence alcohol and nicotine co‐dependence, risk region Alcoholism Alcoholism - complications Alcoholism - genetics Alcoholism and acute alcohol poisoning Biological and medical sciences Black or African American - genetics Genetic Loci - genetics Genetic Predisposition to Disease Genetics, Population Genome-Wide Association Study GWAS Humans Medical genetics Medical sciences Polymorphism, Single Nucleotide - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reproducibility of Results Risk Factors risk region Tobacco Use Disorder - complications Tobacco Use Disorder - genetics Tobacco, tobacco smoking Toxicology White People - genetics
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Zusammenfassung:	The present study searched for replicable risk genomic regions for alcohol and nicotine co‐dependence using a genome‐wide association strategy. The data contained a total of 3,143 subjects including 818 European‐American (EA) cases with alcohol and nicotine co‐dependence, 1,396 EA controls, 449 African‐American (AA) cases, and 480 AA controls. We performed separate genome‐wide association analyses in EAs and AAs and a meta‐analysis to derive combined P‐values, and calculated the genome‐wide false discovery rate (FDR) for each SNP. Regions with P
ISSN:	1552-4841 1552-485X 1552-485X
DOI:	10.1002/ajmg.b.32047