Plants and Animals Share Functionally Common Bacterial Virulence Factors

By exploiting the ability of Pseudomonas aeruginosa to infect a variety of vertebrate and nonvertebrate hosts, we have developed model systems that use plants and nematodes as adjuncts to mammalian models to help elucidate the molecular basis of P. aeruginosa pathogenesis. Our studies reveal a remar...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-08, Vol.97 (16), p.8815-8821
Hauptverfasser:	Rahme, Laurence G., Ausubel, Frederick M., Cao, Hui, Drenkard, Eliana, Goumnerov, Boyan C., Lau, Gee W., Mahajan-Miklos, Shalina, Plotnikova, Julia, Tan, Man-Wah, Tsongalis, John, Walendziewicz, Cynthia L., Tompkins, Ronald G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arabidopsis - microbiology Bacteria Biological Evolution Burns - microbiology Flowers & plants Genetic screening Infections Leaves Mice Molecular biology Nematoda Nematodes Papers from the National Academy of Sciences Colloquium on Virulence and Defense in Host-Pathogen Interactions: Common Features between Plants and Animals Pathogenesis Pathogens Plant diseases Plants Pseudomonas aeruginosa Pseudomonas aeruginosa - pathogenicity Virulence Virulence factors
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Beschreibung
Zusammenfassung:	By exploiting the ability of Pseudomonas aeruginosa to infect a variety of vertebrate and nonvertebrate hosts, we have developed model systems that use plants and nematodes as adjuncts to mammalian models to help elucidate the molecular basis of P. aeruginosa pathogenesis. Our studies reveal a remarkable degree of conservation in the virulence mechanisms used by P. aeruginosa to infect hosts of divergent evolutionary origins.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.97.16.8815