Facile synthesis of mutagen X (MX): 3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one

Facile synthesis of mutagen X (MX): 3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one

3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one (mutagen X, MX) was synthesized in six steps from commercially-available and inexpensive starting materials (27% overall yield). This synthesis enables the preparation of MX analogs and does not require the use of chlorine gas, as do previously re...

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Veröffentlicht in:Tetrahedron letters 2012-06, Vol.53 (25), p.3144-3146
Hauptverfasser: Velvadapu, Venkata, McDonnell, Mark E., Jaffe, Eileen K., Reitz, Allen B.
Format: Artikel
Sprache:eng
Schlagworte:
Analogs
chemical reactions
chemical structure
Chlorine
Furanone
Mucochloric acid
Mutagen X
Mutagenicity
Mutagens
organic compounds
Synthesis (chemistry)
Tetrahedrons
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Beschreibung
Zusammenfassung:3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one (mutagen X, MX) was synthesized in six steps from commercially-available and inexpensive starting materials (27% overall yield). This synthesis enables the preparation of MX analogs and does not require the use of chlorine gas, as do previously reported methods.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.04.044