The influence of von Willebrand factor on factor VIII activity measurements

Background: It has been reported by multiple laboratories that the quantitation of factor (F)VIII by activity‐based assays is influenced by the method, procedure and the quality of reagents used in the assays. Objective: To evaluate the influence of von Willebrand factor (VWF) on FVIII activity in v...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2009-01, Vol.7 (1), p.132-137
Hauptverfasser:	BUTENAS, S., PARHAMI‐SEREN, B., MANN, K. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Coagulation - drug effects Blood Coagulation Tests clotting activity Dose-Response Relationship, Drug Factor VIII - antagonists & inhibitors Factor VIII - pharmacology factor VIII factor VIII products Humans Partial Thromboplastin Time synthetic coagulation proteome tissue factor von Willebrand factor von Willebrand Factor - pharmacology
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Zusammenfassung:	Background: It has been reported by multiple laboratories that the quantitation of factor (F)VIII by activity‐based assays is influenced by the method, procedure and the quality of reagents used in the assays. Objective: To evaluate the influence of von Willebrand factor (VWF) on FVIII activity in vitro. Methods: The activated partial thromboplastin time (APTT) and synthetic coagulation proteome assays were used. Citrated FVIII/VWF‐depleted substrate plasma (SP) (both antigens
ISSN:	1538-7933 1538-7836 1538-7836
DOI:	10.1111/j.1538-7836.2008.03210.x