Pd-Catalyzed Synthesis of ArSCF3 Compounds under Mild Conditions

Good to excellent yields of aryl trifluoromethyl sulfides, which are an important class of compounds in both the pharmaceutical and agrochemical areas, can be achieved under mild conditions by the Pd‐catalyzed reaction of aryl bromides with a trifluoromethylthiolate nucleophile (see scheme).

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2011-08, Vol.50 (32), p.7312-7314
Hauptverfasser:	Teverovskiy, Georgiy, Surry, David S., Buchwald, Stephen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bromides - chemistry Catalysis CS bond formation P ligands palladium Palladium - chemistry Sulfides - chemical synthesis Sulfides - chemistry sulfur synthetic methods Triazines - chemical synthesis Triazines - chemistry
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Beschreibung
Zusammenfassung:	Good to excellent yields of aryl trifluoromethyl sulfides, which are an important class of compounds in both the pharmaceutical and agrochemical areas, can be achieved under mild conditions by the Pd‐catalyzed reaction of aryl bromides with a trifluoromethylthiolate nucleophile (see scheme).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201102543