A Potential Design Flaw of Randomized Trials of Vitamin Supplements

A Potential Design Flaw of Randomized Trials of Vitamin Supplements

Randomized controlled trials (RCTs) are usually conducted on the basis of positive findings from prospective epidemiological studies and laboratory evidence of biological mechanisms. A common view is that the negative findings from the RCTs offer incontrovertible evidence that the nutrient is unrela...

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Veröffentlicht in:JAMA : the journal of the American Medical Association 2011-04, Vol.305 (13), p.1348-1349
Hauptverfasser: Morris, Martha Clare, Tangney, Christine C
Format: Artikel
Sprache:eng
Schlagworte:
Clinical trials
Dementia - prevention & control
Dietary Supplements
Docosahexaenoic Acids - therapeutic use
Epidemiologic Studies
Epidemiology
Humans
Nutrition
Nutritional Status
Randomized Controlled Trials as Topic
Research Design
Vitamin B Complex - therapeutic use
Vitamin E - therapeutic use
Vitamins
Vitamins - therapeutic use
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Beschreibung
Zusammenfassung:Randomized controlled trials (RCTs) are usually conducted on the basis of positive findings from prospective epidemiological studies and laboratory evidence of biological mechanisms. A common view is that the negative findings from the RCTs offer incontrovertible evidence that the nutrient is unrelated to disease and that the epidemiological studies are biased. Here, Morris and Tangney comment on the null findings from three randomized controlled trials of vitamin supplements.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2011.383