Regulation of AMPA receptor trafficking and synaptic plasticity

Regulation of AMPA receptor trafficking and synaptic plasticity

Highlights ► Highly dynamic trafficking of AMPARs regulates synaptic strength and plasticity. ► Subunit-specific AMPAR interacting proteins regulate receptor trafficking. ► Genetic deletion of AMPAR interacting proteins impairs synaptic plasticity, learning, and memory.

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Bibliographische Detailangaben
Veröffentlicht in:Current opinion in neurobiology 2012-06, Vol.22 (3), p.461-469
Hauptverfasser: Anggono, Victor, Huganir, Richard L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Models, Biological
Neurology
Neuronal Plasticity - physiology
Protein Transport - physiology
Psychiatry
Receptors, AMPA - metabolism
Synapses - physiology
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Zusammenfassung:Highlights ► Highly dynamic trafficking of AMPARs regulates synaptic strength and plasticity. ► Subunit-specific AMPAR interacting proteins regulate receptor trafficking. ► Genetic deletion of AMPAR interacting proteins impairs synaptic plasticity, learning, and memory.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2011.12.006