Iron(II)-Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates

Exchanging BF3 by CF3: The title reaction proceeds under exceedingly mild reaction conditions and provides 2‐arylvinyl‐ and 2‐heteroarylvinyl‐substituted substrates with E/Z selectivities of more than 95:5. Experimental observations suggest that the reaction does not proceed through a transmetalatio...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-03, Vol.51 (12), p.2947-2950
Hauptverfasser:	Parsons, Andrew T., Senecal, Todd D., Buchwald, Stephen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Copper - chemistry Ferrous Compounds - chemistry fluorine Fluorine - chemistry homogeneous catalysis iron Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Stereoisomerism trifluoromethylation
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Beschreibung
Zusammenfassung:	Exchanging BF3 by CF3: The title reaction proceeds under exceedingly mild reaction conditions and provides 2‐arylvinyl‐ and 2‐heteroarylvinyl‐substituted substrates with E/Z selectivities of more than 95:5. Experimental observations suggest that the reaction does not proceed through a transmetalation of the RBF3K species to the iron catalyst.
ISSN:	1433-7851 1521-3773 1521-3773
DOI:	10.1002/anie.201108267