Neurological impacts from inhalation of pollutants and the nose–brain connection

The effects of inhaled particles have focused heavily on the respiratory and cardiovascular systems. Most studies have focused on inhaled metals, whereas less information is available for other particle types regarding the effects on the brain and other extra-pulmonary organs. We review here the key...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2012-08, Vol.33 (4), p.838-841
Hauptverfasser:	Lucchini, R.G., Dorman, D.C., Elder, A., Veronesi, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Air Pollutants - adverse effects Air pollution Animals Biological and medical sciences Body Burden Environmental Monitoring Environmental pollutants toxicology Humans Inhalation Exposure - adverse effects Medical sciences Nervous System - drug effects Nervous System - physiopathology Neurotoxicity Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - physiopathology Nose - drug effects Nose - physiopathology Olfactory Pathways - drug effects Olfactory Pathways - physiopathology Olfactory tract Risk Assessment Risk Factors Toxicology
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Zusammenfassung:	The effects of inhaled particles have focused heavily on the respiratory and cardiovascular systems. Most studies have focused on inhaled metals, whereas less information is available for other particle types regarding the effects on the brain and other extra-pulmonary organs. We review here the key available literature on nanoparticle uptake and transport through the olfactory pathway, the experimental data from animal and in vitro studies, and human epidemiological observations. Nanoparticles (
ISSN:	0161-813X 1872-9711
DOI:	10.1016/j.neuro.2011.12.001