Screening Low-Frequency SNPS From Genome-Wide Association Study Reveals a New Risk Allele for Progression to AIDS

BACKGROUND:Seven genome-wide association studies (GWAS) have been published in AIDS, and only associations in the HLA region on chromosome 6 and CXCR6 have passed genome-wide significance. METHODS:We reanalyzed the data from 3 previously published GWAS, targeting specifically low-frequency SNPs (min...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2011-03, Vol.56 (3), p.279-284
Hauptverfasser:	Clerc, Sigrid Le, Coulonges, Cédric, Delaneau, Olivier, Manen, Danielle Van, Herbeck, Joshua T, Limou, Sophie, An, Ping, Martinson, Jeremy J, Spadoni, Jean-Louis, Therwath, Amu, Veldink, Jan H, van den Berg, Leonard H, Taing, Lieng, Labib, Taoufik, Mellak, Safa, Montes, Matthieu, Delfraissy, Jean-François, Schächter, François, Winkler, Cheryl, Froguel, Philippe, Mullins, James I, Schuitemaker, Hanneke, Zagury, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - genetics Adult AIDS Alleles Biological and medical sciences Chromosomes Disease Progression Europe Female Fundamental and applied biological sciences. Psychology Genes Genetic Predisposition to Disease Genome-Wide Association Study Genomes GTPase-Activating Proteins - genetics HIV Long-Term Survivors Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Medical screening Microbiology Middle Aged Miscellaneous Polymorphism, Single Nucleotide United States Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	BACKGROUND:Seven genome-wide association studies (GWAS) have been published in AIDS, and only associations in the HLA region on chromosome 6 and CXCR6 have passed genome-wide significance. METHODS:We reanalyzed the data from 3 previously published GWAS, targeting specifically low-frequency SNPs (minor allele frequency
ISSN:	1525-4135 1944-7884 1944-7884
DOI:	10.1097/QAI.0b013e318204982b