Post injury changes in the properties of mesenchymal stem cells derived from human anterior cruciate ligaments

Purpose The anterior cruciate ligament (ACL) rarely heals spontaneously after rupture. Mesenchymal stem cells (MSCs) contribute to healing in various tissues, therefore, they may also have a key role in healing after ACL rupture. The purpose of this study was to investigate the properties of MSCs in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International orthopaedics 2012-07, Vol.36 (7), p.1515-1522
Hauptverfasser:	Nohmi, Shuya, Yamamoto, Yuji, Mizukami, Hiroki, Ishibashi, Yasuyuki, Tsuda, Eiichi, Maniwa, Keiichiro, Yagihashi, Soroku, Motomura, Shigeru, Toh, Satoshi, Furukawa, Ken-Ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adipocytes - cytology Adipocytes - metabolism Adolescent Adult Anterior Cruciate Ligament - pathology Anterior Cruciate Ligament Injuries Antigens, Surface - metabolism Biomarkers - metabolism Cell Differentiation Child Chondrocytes - cytology Chondrocytes - metabolism Colony-Forming Units Assay Female Humans Male Medicine Medicine & Public Health Mesenchymal Stromal Cells - pathology Mesenchymal Stromal Cells - physiology Middle Aged Original Paper Orthopedics Osteocytes - cytology Osteocytes - metabolism Rupture Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Purpose The anterior cruciate ligament (ACL) rarely heals spontaneously after rupture. Mesenchymal stem cells (MSCs) contribute to healing in various tissues, therefore, they may also have a key role in healing after ACL rupture. The purpose of this study was to investigate the properties of MSCs in ruptured ACLs. Methods Human ACL samples were harvested from patients undergoing primary ACL reconstruction, and samples were classified by the number of days post rupture (phase I
ISSN:	0341-2695 1432-5195
DOI:	10.1007/s00264-012-1484-y