RFLP for the human transforming growth factor beta-1 gene (TGFB) on chromosome 19

phTGFB-2 contains a 2.1 kb cDNA insert cloned into the EcoRI site of pBR327. BsmI digestion reveals polymorphic fragments of 16 kb (allele 1) and 13 kb (allele 2) and also shows a faintly hybridizing band at 13.2 kb. Co-dominant inheritance was demonstrated in three families. SphI reveals a possible...

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Veröffentlicht in:	Nucleic acids research 1988-08, Vol.16 (16), p.8202-8202
Hauptverfasser:	ARDINGER, H. H, ARDINGER, R. H, BELL, G. I, MURRAY, J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	550200 - Biochemistry ANIMALS BASIC BIOLOGICAL SCIENCES Biological and medical sciences CELL CONSTITUENTS CHROMOSOMES Chromosomes, Human, Pair 19 Classical genetics, quantitative genetics, hybrids DNA DNA HYBRIDIZATION DNA SEQUENCING Fundamental and applied biological sciences. Psychology GENES Genetics of eukaryotes. Biological and molecular evolution GROWTH FACTORS Growth Substances - genetics HETEROCHROMOSOMES Human HUMAN POPULATIONS Humans HYBRIDIZATION MAMMALS MAN MITOGENS NUCLEIC ACIDS ORGANIC COMPOUNDS Peptides - genetics PLASMIDS Polymorphism, Genetic Polymorphism, Restriction Fragment Length POPULATIONS PRIMATES PROTEINS RECOMBINANT DNA RFLPS STRUCTURAL CHEMICAL ANALYSIS Transforming Growth Factors VERTEBRATES
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Beschreibung
Zusammenfassung:	phTGFB-2 contains a 2.1 kb cDNA insert cloned into the EcoRI site of pBR327. BsmI digestion reveals polymorphic fragments of 16 kb (allele 1) and 13 kb (allele 2) and also shows a faintly hybridizing band at 13.2 kb. Co-dominant inheritance was demonstrated in three families. SphI reveals a possible RFLP with alleles of 15 kb and 13.5 kb.
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/16.16.8202