Thiacycloalkynes for Copper-Free Click Chemistry

The heteroatom helps! The introduction of an endocyclic sulfur atom enables fine‐tuning of the reactivity and stability of thiacycloalkynes for copper‐free click chemistry. The stabilizing effect of the endocyclic sulfur atom allows the use of highly activated seven‐membered rings as reagents for bi...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-03, Vol.51 (10), p.2443-2447
Hauptverfasser:	de Almeida, Gabriela, Sletten, Ellen M., Nakamura, Hitomi, Palaniappan, Krishnan K., Bertozzi, Carolyn R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated Alkynes - chemistry Azides - chemistry bioorthogonal chemistry Click Chemistry Communications Copper - chemistry Cycloparaffins - chemistry Molecular Structure protein modifications Stability strained alkynes Sulfur sulfur heterocycles
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The heteroatom helps! The introduction of an endocyclic sulfur atom enables fine‐tuning of the reactivity and stability of thiacycloalkynes for copper‐free click chemistry. The stabilizing effect of the endocyclic sulfur atom allows the use of highly activated seven‐membered rings as reagents for bioorthogonal copper‐free click chemistry.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201106325