Pt-Catalyzed Cyclization/1,2-Migration for the Synthesis of Indolizines, Pyrrolones, and Indolizinones

Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily...

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Veröffentlicht in:	Organic letters 2007-03, Vol.9 (6), p.1169-1171
Hauptverfasser:	Smith, Cameron R, Bunnelle, Eric M, Rhodes, Allison J, Sarpong, Richmond
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Catalysis Cyclization Heterocyclic Compounds - chemical synthesis Indolizines - chemical synthesis Isomerism Models, Chemical Platinum - chemistry Propanols - chemistry Pyridines - chemistry Pyrroles - chemical synthesis
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Beschreibung
Zusammenfassung:	Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily available substrates.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol0701971