Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry

Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2...

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Veröffentlicht in:	Translational psychiatry 2012-06, Vol.2 (6), p.e127-e127
Hauptverfasser:	Kühn, S, Musso, F, Mobascher, A, Warbrick, T, Winterer, G, Gallinat, J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1595/1554 692/699/476/1799 692/700/1421/65 Adult Behavioral Sciences Biological Psychology Female Hippocampus - anatomy & histology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medicine Medicine & Public Health Neurosciences Organ Size Original original-article Pharmacotherapy Psychiatric Status Rating Scales Psychiatry Schizophrenia - pathology
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Zusammenfassung:	Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields.
ISSN:	2158-3188 2158-3188
DOI:	10.1038/tp.2012.51