Lesioning noradrenergic neurons of the locus coeruleus in C57Bl/6 mice with unilateral 6-hydroxydopamine injection, to assess molecular, electrophysiological and biochemical changes in noradrenergic signaling

Highlights ► 6-OHDA reduces LC neurons specifically. ► No compensation of surviving LC neurons. ► Reduced NET and NE concentration in specific forebrain regions. ► No change in adrenoreceptors. ► Evidence of bi-lateral innervation from LC.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2012-08, Vol.216, p.143-157
Hauptverfasser:	Szot, P, Knight, L, Franklin, A, Sikkema, C, Foster, S, Wilkinson, C.W, White, S.S, Raskind, M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Agents - toxicity Adrenergic Neurons - drug effects Adrenergic Neurons - metabolism Animals Behavior, Animal Biological and medical sciences Brain Mapping Disease Models, Animal dopamine β-hydroxylase Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Electrophysiological Phenomena frontal cortex Fundamental and applied biological sciences. Psychology hippocampus Hippocampus - metabolism Locus Coeruleus - drug effects Locus Coeruleus - metabolism Male Mice Mice, Inbred C57BL Neurology Norepinephrine - metabolism norepinephrine transporter Oxidopamine - toxicity RNA, Messenger - metabolism Signal Transduction - drug effects single-unit extracellular electrophysiology Substantia Nigra - drug effects Substantia Nigra - metabolism tyrosine hydroxylase Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► 6-OHDA reduces LC neurons specifically. ► No compensation of surviving LC neurons. ► Reduced NET and NE concentration in specific forebrain regions. ► No change in adrenoreceptors. ► Evidence of bi-lateral innervation from LC.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.04.046