Paget’s disease of bone: a review of epidemiology, pathophysiology and management

Paget’s disease of bone is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. Fortunately, effective pharmacologic therapy, primarily with potent bisphosphonates, is now available to treat patients with co...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Therapeutic Advances in Musculoskeletal Disease 2009-12, Vol.1 (2), p.107-125
1. Verfasser: Shaker, Joseph L.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 125
container_issue 2
container_start_page 107
container_title Therapeutic Advances in Musculoskeletal Disease
container_volume 1
creator Shaker, Joseph L.
description Paget’s disease of bone is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. Fortunately, effective pharmacologic therapy, primarily with potent bisphosphonates, is now available to treat patients with complications or symptoms. This review of Paget’s disease of bone will include epidemiology and pathophysiology, complications and clinical findings, indications for treatment, and the drugs currently available to treat this condition.
doi_str_mv 10.1177/1759720X09351779
format Article
fullrecord <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3383486</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1759720X09351779</sage_id><sourcerecordid>1034795516</sourcerecordid><originalsourceid>FETCH-LOGICAL-c645t-59687a39800181c16216837331789e6ead3f61171b52b9a633717278de13f3453</originalsourceid><addsrcrecordid>eNp1kc1q3DAUhUVoyF-zz6oYuukiTnV1rb8uCiWkbSDQQlvITmjs6xkH23ItT8rs8hp5vTxJNUwybQNdSbr67rk6OoydAD8D0PotaGm14Nfcokxnu8MO1qVcCzAvtnt-vc8OY7zhXFluYY_tC2E0L1AcsG9f_Zymh7v7mFVNJB8pC3U2Cz29y3w20m1Dv9YVGpqKuia0Yb46zQY_LcKwWMVNIfN9lXW-T1Id9dNLtlv7NtLx43rEfny8-H7-Ob_68uny_MNVXqpCTrm0ymiP1nAOBkpQApRBjQjaWFLkK6xVsgkzKWbWK0QNWmhTEWCNhcQj9n6jOyxnHVVlGj361g1j0_lx5YJv3L83fbNw83DrEA0WRiWBN48CY_i5pDi5roklta3vKSyjA46FtlLCGn39DL0Jy7FP9pzAArnkheaJ4huqHEOMI9XbxwB368Tc88RSy6u_TWwbniJKQL4BYvreP1P_K_gb2yidpA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2343050470</pqid></control><display><type>article</type><title>Paget’s disease of bone: a review of epidemiology, pathophysiology and management</title><source>Sage Journals GOLD Open Access 2024</source><creator>Shaker, Joseph L.</creator><creatorcontrib>Shaker, Joseph L.</creatorcontrib><description>Paget’s disease of bone is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. Fortunately, effective pharmacologic therapy, primarily with potent bisphosphonates, is now available to treat patients with complications or symptoms. This review of Paget’s disease of bone will include epidemiology and pathophysiology, complications and clinical findings, indications for treatment, and the drugs currently available to treat this condition.</description><identifier>ISSN: 1759-720X</identifier><identifier>EISSN: 1759-7218</identifier><identifier>DOI: 10.1177/1759720X09351779</identifier><identifier>PMID: 22870432</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Bone diseases ; Disease management ; Epidemiology ; Immunotherapy ; Pathology ; Review</subject><ispartof>Therapeutic Advances in Musculoskeletal Disease, 2009-12, Vol.1 (2), p.107-125</ispartof><rights>The Author(s), 2009.</rights><rights>The Author(s), 2009.. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><rights>The Author(s), 2009 2009 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c645t-59687a39800181c16216837331789e6ead3f61171b52b9a633717278de13f3453</citedby><cites>FETCH-LOGICAL-c645t-59687a39800181c16216837331789e6ead3f61171b52b9a633717278de13f3453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383486/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383486/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,727,780,784,792,885,21966,27853,27922,27924,27925,44945,45333,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1759720X09351779?utm_source=summon&amp;utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22870432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shaker, Joseph L.</creatorcontrib><title>Paget’s disease of bone: a review of epidemiology, pathophysiology and management</title><title>Therapeutic Advances in Musculoskeletal Disease</title><addtitle>Ther Adv Musculoskelet Dis</addtitle><description>Paget’s disease of bone is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. Fortunately, effective pharmacologic therapy, primarily with potent bisphosphonates, is now available to treat patients with complications or symptoms. This review of Paget’s disease of bone will include epidemiology and pathophysiology, complications and clinical findings, indications for treatment, and the drugs currently available to treat this condition.</description><subject>Bone diseases</subject><subject>Disease management</subject><subject>Epidemiology</subject><subject>Immunotherapy</subject><subject>Pathology</subject><subject>Review</subject><issn>1759-720X</issn><issn>1759-7218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kc1q3DAUhUVoyF-zz6oYuukiTnV1rb8uCiWkbSDQQlvITmjs6xkH23ItT8rs8hp5vTxJNUwybQNdSbr67rk6OoydAD8D0PotaGm14Nfcokxnu8MO1qVcCzAvtnt-vc8OY7zhXFluYY_tC2E0L1AcsG9f_Zymh7v7mFVNJB8pC3U2Cz29y3w20m1Dv9YVGpqKuia0Yb46zQY_LcKwWMVNIfN9lXW-T1Id9dNLtlv7NtLx43rEfny8-H7-Ob_68uny_MNVXqpCTrm0ymiP1nAOBkpQApRBjQjaWFLkK6xVsgkzKWbWK0QNWmhTEWCNhcQj9n6jOyxnHVVlGj361g1j0_lx5YJv3L83fbNw83DrEA0WRiWBN48CY_i5pDi5roklta3vKSyjA46FtlLCGn39DL0Jy7FP9pzAArnkheaJ4huqHEOMI9XbxwB368Tc88RSy6u_TWwbniJKQL4BYvreP1P_K_gb2yidpA</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Shaker, Joseph L.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091201</creationdate><title>Paget’s disease of bone: a review of epidemiology, pathophysiology and management</title><author>Shaker, Joseph L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c645t-59687a39800181c16216837331789e6ead3f61171b52b9a633717278de13f3453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Bone diseases</topic><topic>Disease management</topic><topic>Epidemiology</topic><topic>Immunotherapy</topic><topic>Pathology</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shaker, Joseph L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Therapeutic Advances in Musculoskeletal Disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Shaker, Joseph L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paget’s disease of bone: a review of epidemiology, pathophysiology and management</atitle><jtitle>Therapeutic Advances in Musculoskeletal Disease</jtitle><addtitle>Ther Adv Musculoskelet Dis</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>1</volume><issue>2</issue><spage>107</spage><epage>125</epage><pages>107-125</pages><issn>1759-720X</issn><eissn>1759-7218</eissn><abstract>Paget’s disease of bone is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. Fortunately, effective pharmacologic therapy, primarily with potent bisphosphonates, is now available to treat patients with complications or symptoms. This review of Paget’s disease of bone will include epidemiology and pathophysiology, complications and clinical findings, indications for treatment, and the drugs currently available to treat this condition.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22870432</pmid><doi>10.1177/1759720X09351779</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier ISSN: 1759-720X
ispartof Therapeutic Advances in Musculoskeletal Disease, 2009-12, Vol.1 (2), p.107-125
issn 1759-720X
1759-7218
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3383486
source Sage Journals GOLD Open Access 2024
subjects Bone diseases
Disease management
Epidemiology
Immunotherapy
Pathology
Review
title Paget’s disease of bone: a review of epidemiology, pathophysiology and management
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T13%3A46%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_AFRWT&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Paget%E2%80%99s%20disease%20of%20bone:%20a%20review%20of%20epidemiology,%20pathophysiology%20and%20management&rft.jtitle=Therapeutic%20Advances%20in%20Musculoskeletal%20Disease&rft.au=Shaker,%20Joseph%20L.&rft.date=2009-12-01&rft.volume=1&rft.issue=2&rft.spage=107&rft.epage=125&rft.pages=107-125&rft.issn=1759-720X&rft.eissn=1759-7218&rft_id=info:doi/10.1177/1759720X09351779&rft_dat=%3Cproquest_AFRWT%3E1034795516%3C/proquest_AFRWT%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2343050470&rft_id=info:pmid/22870432&rft_sage_id=10.1177_1759720X09351779&rfr_iscdi=true