Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation

Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation

CD1d-restricted invariant (i)NKT cells are innate-like, lipid-reactive T lymphocytes implicated in the control of infections, cancer and autoimmunity. Our study suggests that the reconstitution of the peripheral iNKT cell compartment, following HLA-haploidentical hematopoietic stem cell transplantat...

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Veröffentlicht in:Oncoimmunology 2012-05, Vol.1 (3), p.355-357
Hauptverfasser: Casorati, Giulia, de Lalla, Claudia, Dellabona, Paolo
Format: Artikel
Sprache:eng
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Binding
Biology
Bioscience
Calcium
Cancer
CD1d
Cell
Cycle
immunesurveillance
immunotherapy
Landes
leukemia
NKT cells
Organogenesis
Proteins
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Zusammenfassung:CD1d-restricted invariant (i)NKT cells are innate-like, lipid-reactive T lymphocytes implicated in the control of infections, cancer and autoimmunity. Our study suggests that the reconstitution of the peripheral iNKT cell compartment, following HLA-haploidentical hematopoietic stem cell transplantation, associates with leukemia control in children affected by different hematological malignancies.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.18399