A cooperative interaction between LPHN3 and 11q doubles the risk for ADHD

In previous studies of a genetic isolate, we identified significant linkage of attention deficit hyperactivity disorder (ADHD) to 4q, 5q, 8q, 11q and 17p. The existence of unique large size families linked to multiple regions, and the fact that these families came from an isolated population, we hyp...

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Veröffentlicht in:	Molecular psychiatry 2012-07, Vol.17 (7), p.741-747
Hauptverfasser:	Jain, M, Vélez, J I, Acosta, M T, Palacio, L G, Balog, J, Roessler, E, Pineda, D, Londoño, A C, Palacio, J D, Arbelaez, A, Lopera, F, Elia, J, Hakonarson, H, Seitz, C, Freitag, C M, Palmason, H, Meyer, J, Romanos, M, Walitza, S, Hemminger, U, Warnke, A, Romanos, J, Renner, T, Jacob, C, Lesch, K-P, Swanson, J, Castellanos, F X, Bailey-Wilson, J E, Arcos-Burgos, M, Muenke, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - genetics Attention deficit hyperactivity disorder Behavioral Sciences Biological Psychology Brain Brain - metabolism Case-Control Studies Child & adolescent psychiatry Choline - metabolism Chromosomes, Human, Pair 11 - genetics Data processing Development and progression Dopamine D2 receptors Gene expression Genetic aspects Genetic Linkage - genetics Genetic Predisposition to Disease - genetics Genetic susceptibility Genetics Genomes Glutamine - metabolism Humans Inositol - metabolism Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Medicine Medicine & Public Health Metabolism Methylphenidate - therapeutic use Neurosciences Original original-article Pharmacogenetics Pharmacotherapy Physiological aspects Polymorphism, Single Nucleotide - genetics Protons Psychiatry Psychobiology Psychotherapy Receptors, G-Protein-Coupled - genetics Receptors, Peptide - genetics Risk factors Single-nucleotide polymorphism Stimulants
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Zusammenfassung:	In previous studies of a genetic isolate, we identified significant linkage of attention deficit hyperactivity disorder (ADHD) to 4q, 5q, 8q, 11q and 17p. The existence of unique large size families linked to multiple regions, and the fact that these families came from an isolated population, we hypothesized that two-locus interaction contributions to ADHD were plausible. Several analytical models converged to show significant interaction between 4q and 11q ( P
ISSN:	1359-4184 1476-5578
DOI:	10.1038/mp.2011.59