Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study

Background. The immune deficiency of human immunodeficiency virus (HIV) infection is not fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but optimal dosing and mechanisms of cellular increases need to be defined. Methods. We performed a randomized placebo-controll...

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Veröffentlicht in:	Clinical infectious diseases 2012-07, Vol.55 (2), p.291-300
Hauptverfasser:	Lévy, Y., Sereti, I., Tambussi, G., Routy, J. P., Lelièvre, J. D., Delfraissy, J. F., Molina, J. M., Fischl, M., Goujard, C., Rodriguez, B., Rouzioux, C., Avettand-Fenoël, V., Croughs, T., Beq, S., Morre, M., Poulin, J. F., Sekaly, R. P., Thiebaut, R., Lederman, M. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - administration & dosage Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiretroviral Therapy, Highly Active - methods Antiviral agents Biological and medical sciences Blood CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - immunology Clinical trials Cytokines DNA Dosage Drug dosages HIV HIV Infections - drug therapy HIV Infections - immunology HIV/AIDS Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunologic Factors - administration & dosage Immunologic Factors - adverse effects Immunopathology Infectious diseases Interleukin-7 - administration & dosage Interleukin-7 - adverse effects Interleukins Medical sciences Memory Pharmacology. Drug treatments Placebos Placebos - administration & dosage Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects RNA T cell antigen receptors T cell receptors T lymphocytes Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	Background. The immune deficiency of human immunodeficiency virus (HIV) infection is not fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but optimal dosing and mechanisms of cellular increases need to be defined. Methods. We performed a randomized placebo-controlled dose escalation (10, 20 and 30 μg/kg) trial of 3 weekly doses of recombinant human IL-7 (rhIL-7) in ARV-treated HIV-infected persons with CD4 T-cell counts between 101 and 400 cells/μL and plasma HIV levels
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/cis383